Gamma interferon production by peripheral blood lymphocytes in patients with gastric cancer.
نویسندگان
چکیده
The production of gamma interferon (IFN-y) by peripheral blood lymphocytes was studied in 38 patients with gastric cancer. Purified protein derivative (PPO) as a specific antigen and three kinds of mitogens, phytohemagglutinin-P (PHA), concanavalin A(Con A) and pokeweed mitogen (PWMl, were used as IFN-y inducers. IFN-y production by lymphocytes was markedly reduced in patients with gastric cancer when these inducers were used. Reduction of IFN-y production was observed more often in patients of Stage IV than in those of Stage I when PPO or Con A was used. PPO-induced IFN-y production significantly increased in patients who were operated on curatively, while it decreased in those who were operated on noncuratively. IFN-y production by lymphocytes, especially when PPO is used as an IFN-y inducer, reflects cell-mediated immunity in patients with gastric cancer. It may be useful as quantitative parameter to predict therapeutic effects and prognosis in cancer patients.
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عنوان ژورنال:
- Nagoya journal of medical science
دوره 46 1-4 شماره
صفحات -
تاریخ انتشار 1984